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Article
April 19, 1947

PENICILLIN THERAPY OF GONOCOCCIC ENDOCARDITIS OF THE PULMONARY VALVE

Author Affiliations

Washington, D. C.

From the Central Dispensary and Emergency Hospital and the Department of Medicine, George Washington University School of Medicine.

JAMA. 1947;133(16):1205-1207. doi:10.1001/jama.1947.62880160001007
Abstract

In the past gonococcic endocarditis has been of interest primarily as a diagnostic problem. The mortality rate in acute endocarditis due to the gonococcus approached 100 per cent. With the advent of the sulfonamide drugs and the antibiotics, the treatment of gonococcic endocarditis is not without hope. The National Research Council received reports of penicillin therapy in 5 cases of acute gonococcic endocarditis. Recoveries or clinical arrests were reported in 3 of these cases.1

REPORT OF A CASE  A Negro girl aged 18 was admitted to the hospital on March 21, 1945. Her chief complaints were pain in the lower part of the abdomen and constant headache of one week's duration, and vomiting for one day.The present illness began two weeks earlier, at which time she first noted weakness, listlessness and easy fatigability. She had been seen by a local physician because of delayed menstruation. With the onset

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