It has been reported1 that the administration of sulfonamides or penicillin to patients with amebic colitis is not infrequently accompanied with symptomatic and objective improvement in the course of the infection despite the persistence of Endamoeba histolytica in the stools and the colonic lesions. In fact, many clinicians routinely administer antimicrobial agents in addition to amebicidal drugs at some time in the course of therapy of amebiasis. The presumed rationale for this procedure is apparently the reduction in the total number or the elimination of certain enteric organisms which may invade the amebic lesion or contribute essentially to the maintained growth and pathogenicity of E. histolytica. The role of intestinal bacteria in amebiasis has been the subject of a great deal of speculation, and the difficulty of maintaining cultures of E. histolytica without living bacteria or bacterial filtrates or other protozoa has to date not been entirely overcome. It
MOST H, MILLER JW, GROSSMAN EB, CONAN N. TREATMENT OF AMEBIASIS WITH BACITRACIN. JAMA. 1950;143(9):792–794. doi:10.1001/jama.1950.02910440010005
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: