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July 1, 1950


Author Affiliations
New York
From the Departments of Preventive Medicine and Medicine, New York University College of Medicine and the New York Regional Office Medical Clinic, Veterans Administration.
JAMA. 1950;143(9):792-794. doi:10.1001/jama.1950.02910440010005

It has been reported1 that the administration of sulfonamides or penicillin to patients with amebic colitis is not infrequently accompanied with symptomatic and objective improvement in the course of the infection despite the persistence of Endamoeba histolytica in the stools and the colonic lesions. In fact, many clinicians routinely administer antimicrobial agents in addition to amebicidal drugs at some time in the course of therapy of amebiasis. The presumed rationale for this procedure is apparently the reduction in the total number or the elimination of certain enteric organisms which may invade the amebic lesion or contribute essentially to the maintained growth and pathogenicity of E. histolytica. The role of intestinal bacteria in amebiasis has been the subject of a great deal of speculation, and the difficulty of maintaining cultures of E. histolytica without living bacteria or bacterial filtrates or other protozoa has to date not been entirely overcome. It