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Article
April 10, 1954

INVESTIGATION OF USE OF AUROTHIOGLYCANIDE (LAURON) IN RHEUMATOID ARTHRITISPRELIMINARY REPORT OF TOXICITY AND THERAPEUTIC EFFECTS OF A FINE SUSPENSION

JAMA. 1954;154(15):1263-1265. doi:10.1001/jama.1954.02940490027007
Abstract

In spite of the introduction of hormonal agents for the treatment of rheumatoid arthritis, chrysotherapy still remains a method of treatment favored by many because of certain distinct advantages: gold compounds may arrest the active process and prevent progression of the disease and ultimate crippling of the patient; gold salts cause no disturbance in hormonal function and do not upset the salt and water metabolism; and these compounds offer more than simple palliation, which salicylates and other analgesic agents do not do. The mechanism of the action of gold salts in the treatment of rheumatoid arthritis remains unknown, although it has been shown that the administration of gold salts markedly increases the bacteriostatic power of the serum against hemolytic streptococci and other organisms.1 There are three main types of gold preparations that have been used in rheumatoid arthritis: water-soluble, water-insoluble, and colloidal compounds. Soluble gold compounds have been studied

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