The purpose of this report is to present data regarding the rationale and effectiveness of heparin in the treatment of venous thromboembolic disease and to propose an improved method of heparinization, which is both safe and practical.
Although thromboses in the calf and plantar veins were observed for many years, the relationship between these minimal thromboses and fatal pulmonary emboli has been emphasized only in the past decade. It remained for Rössle,1 Neumann2 and Frykholm3 to elaborate the anatomic development of pulmonary emboli and for Homans4 and Bauer5 to apply clinical and radiographic criteria by which aseptic deep calf thrombi could be recognized in their incipiency prior to the occurrence of pulmonary embolization. Based on the functional anatomy and clinical pathology of pulmonary embolization, Homans,6 Bancroft,7 Ochsner,8 Allen and his co-workers9 and Bauer10 then elaborated definitive principles of
LOEWE L, HIRSCH E. HEPARIN IN THE TREATMENT OF THROMBOEMBOLIC DISEASE. JAMA. 1947;133(17):1263–1268. doi:10.1001/jama.1947.02880170009003
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