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April 26, 1947

Current Comment

JAMA. 1947;133(17):1284. doi:10.1001/jama.1947.02880170030011

EOSINOPHILIC GRANULOMA OF BONE  In 1940 a granulomatous bone lesion was described by Otani and Ehrlich1 and by Lichtenstein and Jaffe,2 who named it eosinophilic granuloma of bone; the disease is now well established under that name. Recently three reports3 of 10 new cases were published, bringing the number of reported cases to 63, most of them from this country. Consequently the granuloma should be considered in the diagnosis of bone diseases, especially those of localized nature occurring in the early decades of life. Briefly stated, this condition is a more or less self-limited osteolytic, granulomatous process of unknown but possibly infectious nature. In the early stages eosinophilic leukocytes dominate the cellular picture of the lesion; later vacuolated mononuclear cells—foam cells—are more characteristic; healing takes place by fibroblastic proliferation and regeneration of bone. The disease may occur in any part of the skeleton proximal to the wrists