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To the Editor:—
Some persons who have received injections of diphtheria toxoid, especially the alum precipitated toxoid, may be sensitized to proteins contained in veal broth and consequently develop urticaria following injection of other veal broth preparations.To avoid the development of urticaria in such persons during the course of immunization against scarlet fever, the medium in which scarlet fever toxin is produced has been changed to one which contains no meat infusion. Use of this medium results in a toxin containing considerably less protein and a marked reduction in the incidence of urticaria.
Dick GH. CHANGE IN MEDIUM FOR SCARLET FEVER TOXIN. JAMA. 1939;113(12):1150. doi:10.1001/jama.1939.02800370066027
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