Procaine amide (Pronestyl) was synthesized in 1949 in the course of a search for a drug similar in action to procaine. It was desirable that the drug be longer acting and cause less nervous system stimulation and less vasomotor depression. Procaine amide was found to have these advantages. The published data described its use in the treatment of cardiac irregularities, principally ventricular arrhythmias.1 One of us (M. S. S.) has been making clinical studies of procaine and procaine amide given orally in the treatment of such conditions as arthritis, causalgia, vasospasm, pruritis, pain, and hiccup. Because of the advantages of procaine amide listed above, it was substituted for procaine in these studies of oral administration. It occurred to us that procaine amide administered orally should be given a clinical trial in spastic and related conditions of the upper alimentary tract instead of procaine, which was used in the studies
Sadove MS, Keeley JL, Rooney JA, Guzauskas A. MANAGEMENT WITH PROCAINE AMIDE (PRONESTYL) OF PYLOROSPASM IN INFANTS. JAMA. 1954;154(16):1328–1330. doi:10.1001/jama.1954.02940500008003
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