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To the Editor:—
From the standpoint of the rhinologist, there is one point that seems of particular importance in the discussion of the question concerning the inhalation of cigarette smoke and the increasing incidence of malignant new growths of the lung. This particular point concerns the use of animals as test subjects. Animals subjected to cigarette smoke do not inhale through the mouth, but through the nose, and consequently do not represent the condition of human smoking with inhalation.
Albert P. Seltzer. EXPERIMENTAL ANIMALS AND TOBACCO SMOKE. JAMA. 1954;154(16):1372. doi:10.1001/jama.1954.02940500052028