The importance of infectious relapse in early syphilis has been discussed by many observers.1 In the Cooperative Clinical Group studies2 of 339 cases of mucocutaneous relapse, 84 per cent occurred within the first two years of infection and 91 per cent within two years after treatment had ceased. These figures correspond closely to those of Stokes, Besancon and Schoch,1 who noted 93 per cent of their relapses by the end of the second year of infection, and those of Rosahn,3 who recorded 86.7 per cent over a similar period of time in inadequately treated patients.
Although infectious relapse is largely a phenomenon of the first two years of infection, a not insignificant number of instances of relapse after two years have been reported. Stokes, Besancon and Schoch.1 cited a case of infectious recurrence in the mouth six years after onset of the disease, and of
PARISER H. INFECTIOUS RELAPSE IN SYPHILIS OF MORE THAN TWO YEARS' DURATION. JAMA. 1939;113(13):1206–1208. doi:10.1001/jama.1939.02800380024007
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