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September 23, 1939

THE EXANTHEM OF ACUTE MONONUCLEOSIS

JAMA. 1939;113(13):1215-1216. doi:10.1001/jama.1939.02800380033009
Abstract

In view of the increasing frequency of the recognition of acute mononucleosis and its occasional occurrence in epidemic form, we have felt that it would be worth while to describe further the exanthem that occasionally occurs with it. We are not the first to do so, as Tidy,1 Lyght,2 Sadusk3 and Isaacs4 have mentioned the eruption in articles on the disease.

THE DISEASE  Acute mononucleosis has been known since Pfeiffer described it in detail in 1889 and called it "glandular fever." In brief, it may be described as an acute infectious disease occurring usually in young people and characterized clinically by malaise, fever and glandular swellings. From the laboratory standpoint there is a characteristic blood picture and agglutination test. The typical case begins acutely with sore throat, general malaise and aching, fever and sometimes nausea and vomiting. There is a generalized lymphadenopathy, but the cervical glands,

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