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September 23, 1939

Anemia in Practice: Pernicious Anemia

JAMA. 1939;113(13):1248. doi:10.1001/jama.1939.02800380066032

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This volume represents a detailed discussion of the clinical investigations of pernicious anemia in which the author has participated during the past fifteen years. The importance of treatment in the presence of complications, particularly the neurologic, is stressed and well presented. A briefer and somewhat less comprehensive presentation of certain of the other anemic states is included, apparently for the sake of completeness. The use of liver extract in the treatment of the hemolytic anemias would seem to be somewhat uncritically and over-enthusiastically advocated in the light of the published experience from other clinics and on the basis of the known difference in the pathologic changes in the bone marrow in pernicious anemia (megaloblastic hyperplasia) and in hemolytic jaundice (normoblastic hyperplasia) and of the knowledge of the point in the erythrocyte maturation cycle at which the erythrocyte maturation factor is effective. The treatise has been written by the author that

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