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April 24, 1954


JAMA. 1954;154(17):1452. doi:10.1001/jama.1954.02940510052020

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To the Editor:—  In a recent letter in the correspondence section of The Journal (154:262 [Jan. 16] 1954) and in an editorial in the Journal of Allergy (25:57 [Jan.] 1954), Drs. Lowell and Schiller have critically commented on our experiments on the prophylaxis of allergic disease in early infancy (J. Allergy24:434 [Sept.] 1953; J. A. M. A.153:620 [Oct. 17] 1953). Their criticisms, for the most part, from the standpoint of theoretical statistics, are valid. We recognized that we had not conducted an ideal experiment in that we did not in advance randomly choose which infants were to be in the "experimental group," the "sibling control group," and the "nonrelated control group." This we did because, to the best of our knowledge, there was no way to conduct the experiment in a theoretically ideal manner. The situation resembles the state of affairs of investigations designed to show a connection between

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