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Bertram's book has been revised five years after its first appearance to include the aspects of diabetes which have changed in the interval, especially those which deal with the pathogenesis of the disease and certain questions in therapy. He emphasizes the importance of the influence of the anterior pituitary lobe as an organ effective in the regulation of blood sugar and reviews the investigations of Houssay, Young and Best. The experiments of these authors are believed to confirm the conception that a hormone antagonistic to insulin is produced by the anterior pituitary lobe.
In the section on clinical diabetes Bertram defines diabetes as a chronic disease of the total neuro-endocrine apparatus with a hypofunction of the pancreas in the foreground. A disturbance in the anterior pituitary lobe is etiologically responsible for some cases of diabetes, if not for all. In the etiology he shares the unitarian point of view, already
Die Zuckerkrankheit: Leitfaden für Studierende und Ärzte. JAMA. 1939;113(13):1248–1249. doi:10.1001/jama.1939.02800380066033
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