The occurrence of anemia in association with chronic ulcerative colitis has been a common clinical observation for many years.1 The exact incidence of anemia in this disease, however, has never been accurately studied, nor has there been a careful evaluation of the various factors which are important in its production. There have been a few general statements1b,c in regard to this anemia, but most of them have not been supported by either experimental or statistical data. For example, Haden1c states that in chronic Ulcerative colitis there may be a microcytic hypochromic anemia, a macrocytic anemia or a normocytic one. The hypochromic, microcytic type is said to be the most common variety, being due to chronic hemorrhage and the consequent loss of iron. The macrocytic type is presumably due to a rapid passage of food material through the gastrointestinal tract or to some disturbance in the small
POLLARD HM, BLOCK M, BACHRACH WH. CAUSES AND MANAGEMENT OF ANEMIA ASSOCIATED WITH CHRONIC ULCERATIVE COLITIS. JAMA. 1947;134(4):341–347. doi:10.1001/jama.1947.02880210019005
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