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The authors survey the basic knowledge of yaws and its relation to syphilis. They, hold that the causative agent of the two cannot be differentiated by morphologic, cultural or staining methods but only in their different behavior in the host. The fundamental difference in behavior lies in the fact that Treponema pertenue is positively tropic for the ectoderm and T. pallidum for the mesoderm. The differences in the pathologic and clinical pictures as well as in the stages of development of the immunity and epidemiology are the result of this tropistic difference. A genuine immunity is produced in treponematoses which, when highly developed, shows a group immunity. The heterologous immunity appears later than the homologous. Serologic changes accompany the development of the immunity, which is manifested in a change of incubation period in subsequent infections and in a retuning of the ability of the tissues to react against the treponema.
Über Beziehungen zwischen Framboesie und Syphilis. JAMA. 1932;99(25):2139. doi:10.1001/jama.1932.02740770069037
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