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Article
December 24, 1932

HEAVILY FILTERED HIGH VOLTAGE X-IRRADIATION IN CANCER THERAPY: PROTRACTED TREATMENT

Author Affiliations

From the State Institute for the Study of Malignant Diseases; Burton T. Simpson, M.D., Director.

JAMA. 1932;99(26):2157-2160. doi:10.1001/jama.1932.02740780009003
Abstract

Radiation treatment since its inception has undergone various changes, more especially in the methods of administration.1 While it may be stated as a truism that there is no one roentgenologic method that gives best results in all cases, nevertheless certain technics have been heralded as more efficacious in the treatment of the more radioresistant types of neoplasms. Thus, shortly after the conception of this type of therapy, massive dosage long held sway. Later, the pendulum swung to fractional or divided dosage where the total radiation administered extended over a period of a week to ten days. More recently a still further modification, a fractionated, heavily filtered x-irradiation, prolonged over a moderately long period of fifteen or more days, commonly known as protracted dosage, is being advocated. At the outset, I wish to state that such treatment, while not universally popular at its present stage of development because of its

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