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May 31, 1947


Author Affiliations

Wadsworth General Hospital, Los Angeles.

JAMA. 1947;134(5):479. doi:10.1001/jama.1947.02880220063023

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To the Editor:—  A number of questions arise when one reads the article by Mateer and his associates on hepatic impairment in The Journal, March 29. Their use of screening liver function tests in over 300 healthy individuals resulted in designating about 20 per cent as cases of "subclinical liver impairment." In the absence of exposure to known toxins or infectious agents this percentage appears high. Assuming that this group contains no false positives, what proportion may be expected to emerge as clinical hepatopathies? Has a control group of

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