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June 7, 1947


JAMA. 1947;134(6):555. doi:10.1001/jama.1947.02880230065022

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To the Editor:—  The article on the use of propylthiouracil in thyrotoxicosis by Dr. William S. Reveno (The Journal, April 19, p. 1190) presented some unusual if not distressing data. Of 18 previously untreated cases, 9 were reported with initial basal metabolic rates ranging from plus 9 to plus 15 inclusive. While I am not unaware that thyrotoxicosis may occur with a metabolic rate near plus 15, such an occurrence is decidedly uncommon and should be supported by carefully documented observations. I believe the use of so potent and revolutionary a drug as propylthiouracil certainly demands more care in the selection of cases to be reported.

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