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June 7, 1947

On the Morphology of Blood and Bone-Marrow in Thyrotoxicosis

JAMA. 1947;134(6):562. doi:10.1001/jama.1947.02880230072034

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The author reviews the earlier literature and then reports his own investigation on the peripheral blood and bone marrow findings in thyrotoxicosis. He obtained the bone marrow by sternal aspiration. A control group of 24 surgical patients were studied, excluding those with diseases which might influence the blood or bone marrow characteristically. Twenty-six patients with nontoxic goiter were next studied to compare with 33 patients with thyrotoxicosis. The immediate postoperative findings in the nontoxic group of cases were a proportionate decrease in erythrocytes and hemoglobin and a polymorphonuclear leukocytosis in the peripheral blood. There was often a thrombocytosis and reticulocytosis also. The white cells of the marrow showed little alteration, while the decrease in normoblasts was the most regular and conspicuous feature. Fifty per cent of the patients examined at follow-up examination three months later showed improvement in the red blood cell values but not quite to normal, a distinct

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