Aerosols have been employed at the Mayo Clinic in the treatment of secondary infection associated with bronchiectasis since August 1944. A preliminary report of experience with penicillin aerosol therapy was made in June 1945.1 Particular reference was made to the use of the method in the preparation of patients with bronchiectasis for pulmonary resection. In February 1946 the use of nebulized streptomycin was reported briefly.2
At the present writing, nebulization therapy has been used at the clinic for 86 patients with chronic bronchiectasis. Forty-six of these patients were treated in preparation for surgical resection of portions of the lung. The remaining 40 patients had bilateral bronchiectasis or were not suitable candidates for surgical intervention. In these 40 cases aerosol therapy was instituted in the hope of reducing the volume of pulmonary secretions. In all 86 cases aerosol penicillin was used. However, in 27 cases streptomycin hydrochloride3 was
OLSEN AM. NEBULIZATION THERAPY IN BRONCHIECTASIS: The Use of Penicillin and Streptomycin Aerosols. JAMA. 1947;134(11):947–953. doi:10.1001/jama.1947.02880280023006
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