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June 19, 1954


JAMA. 1954;155(8):769. doi:10.1001/jama.1954.03690260061019

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Treatment of Tuberculosis.  —Drs. Grossman and co-workers of Valparaiso reported the results of treating 90 patients with pulmonary tuberculosis with isoniazid (Revista médica de Valparaiso, September, 1953). The patients were divided into 2 groups; 34% (group 1) received no previous treatment with antibiotics, and the rest (group 2) received antibiotics that, however, were discontinued three months prior to the initiation of treatment with isoniazid. In most patients, the previous antibiotic treatment consisted in the administration of streptomycin and p-aminosalicylic acid (PAS) or streptomycin alone. In group 1 the lesions were exudative in 23%, caseous in 30%, and productive in 40% of the patients. Cavities were present in 77%. The dosage of isoniazid used in this group was 3 to 6 mg. per kilogram of body weight. No toxic reactions were observed. In 23%, streptomycin was added to isoniazid in doses of 1 gm. every three days. In this group

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