In 1942 Keston, Ball, Frantz and Palmer1 reported significant uptake and storage of radioactive iodine (I131) in a metastasis in the femur from a "malignant adenoma" of the thyroid. At necropsy only one of many metastatic lesions examined contained a significant concentration of I130. Histologically this metastasis resembled differentiated thyroid tissue. Other histologically undifferentiated metastases showed no uptake. These authors suggested that effective therapeutic internal irradiation might be achieved in well differentiated thyroid tumors and metastases.
In 1946 Seidlin, Marinelli and Oshry2 recorded the successful treatment with I130 and I131 of a patient with adenocarcinoma of the thyroid, removed twenty-one years previously, with subsequent widespread metastases to the lungs, femur, ribs, vertebrae, ilium and skull. The patient presented clinical and laboratory evidence of hyperthyroidism, and the metastatic lesions were demonstrably avid for radioactive iodine. Subsequent to radioactive iodine therapy there was definite improvement reflected
FREEDBERG AS, URELES AL, LESSES MF, GARGILL SL. PULMONARY METASTATIC LESION SUCCESSFULLY TREATED WITH RADIOACTIVE IODINE: Report of a Case of Pulmonary Metastasis from a Papillary Adenocarcinoma of the Thyroid. JAMA. 1950;144(1):16–19. doi:10.1001/jama.1950.02920010018005
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