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July 10, 1954


JAMA. 1954;155(11):999. doi:10.1001/jama.1954.03690290049015

Malignant Hypertension.  —At the meeting of the Society of Physicians held in Vienna on March 5, 1954, Dr. McMichael of London discussed the treatment of hypertension. In some cases, a cure was obtained by the removal of a kidney or of a pheochromocytoma. Under certain circumstances, a cure of hypertension cannot be obtained by removing its cause. The results of sympathectomy have been disappointing. At present the methonium compounds are the most effective drugs for reducing blood pressure. Because of their undesirable side-effects, their administration must be reserved for the severest cases. Not only disappearance of retinitis but also diminution in the size of the previously enlarged heart may result from the administration of methonium derivatives to patients with malignant hypertension, provided that the effects of the drug on the blood pressure are carefully controlled. Of 24 patients with malignant hypertension so treated, 4 survived for two to four years;

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