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September 2, 1950


JAMA. 1950;144(1):47. doi:10.1001/jama.1950.02920010049012

In 1949 Ragan and associates1 of Columbia University reported a chance observation of delayed healing of wounds in patients treated with pituitary adrenocorticotropic hormone (ACTH). The wounds had occurred as a result of complications unrelated to the basic disease being treated with the hormone. For example, an incised abscess did not form granulation tissue until four days after ACTH therapy had been discontinued. Experimental confirmation of this observation was afterward made on rabbits.2 Skin wounds were made on both ears of six pairs of adult rabbits. One rabbit of each pair was treated twice daily by intramuscular injections of cortisone acetate, for three days before the wound was made and for five to eight days thereafter, until the time they were killed. The development of granulation tissue was delayed in all of the cortisone-treated animals. At both five and eight days after the operation the treated animals showed