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August 9, 1947

THE USE OF NEOSTIGMINE METHYLSULFATE IN INFECTIOUS NEURONITIS: Report of a Case with Involvement of Respiratory Muscles

Author Affiliations

St. Louis

From the Department of Pediatrics, Washington University School of Medicine, and the St. Louis Children's Hospital.

JAMA. 1947;134(15):1235-1237. doi:10.1001/jama.1947.72880320001007

The use of neostigmine has been advocated in the treatment of poliomyelitis1 and other neuromuscular disturbances.2 Whereas clinical results with this and similar drugs are equivocal in poliomyelitis,3 encouraging results have been reported in the treatment of a case of neuronitis.4 The present report concerns a case of infectious neuronitis in which neostigmine effected subjective and objective improvement during a critical period of respiratory difficulty.

REPORT OF CASE  C. V., a white boy aged 10, was admitted to St. Louis Children's Hospital on June 8, 1946. He had been well until two weeks prior to admission when he suffered an illness characterized by fever, malaise, lesions in the mouth and a maculopapular rash which began on the face. The disease was diagnosed as measles by the family physician. Measles was prevalent in the community at the time. Apparently the boy's recovery from this acute illness was