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August 30, 1947


JAMA. 1947;134(18):1535-1540. doi:10.1001/jama.1947.72880350001007

1. Introduction.—  A. A well coordinated investigation to determine the most effective method of utilizing penicillin in the management of syphilis is being conducted on a large scale by civilian investigators under the direction of the Syphilis Study Section, National Institute of Health. This investigation is the continuation of a study initiated during the war and organized with great skill, the results of which were largely vitiated by changes in the composition of commercial penicillin which occurred1 during its course. Since July 1946 the continuing investigation has employed crystalline penicillin G and is comparing the effectiveness of various schedules of this substance by itself and in combination with arsenical and bismuth preparations. The effectiveness of penicillin in oil and beeswax2 will be examined later in the course of the study. Should it prove equally effective, this preparation will have obvious advantages in the outpatient treatment of syphilis.

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