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August 30, 1947

Penicillin in Syphilis

JAMA. 1947;134(18):1576. doi:10.1001/jama.1947.02880350060028

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With characteristic thoroughness Moore presents the essential points of penicillin therapy in easily understandable form. Those interested in the clinical use of penicillin will find the section on penicillin in early syphilis very valuable. The same applies to the chapters on syphilis in pregnancy, congenital syphilis, benign late syphilis, cardiovascular syphilis and ocular syphilis. Following a detailed discussion of treatment in these forms of syphilis the author gives a short, pertinentsummary of results. Nearly half of the text is devoted to fundamental information on the chemistry, pharmacology, therapeutic activity and mode of action of penicillin. The section on the pharmacology of penicillin in the central nervous system contains timely advice, and the chapter on toxicity is of special interest to the practitioner. Those who plan to read this book will be disappointed if expecting to find solutions for all of the problems of penicillin therapy in syphilis. Neither the lapse

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