The value of blood in the prevention of disease rarely depends on the whole tissue. Cohn1 points out that it more often depends on one or more of the cellular, protein or smaller organic constituents. The need is for quite different constituents of the blood in hemophilia or hypertension, measles or anemia, hemorrhage or infectious hepatitis, edema, shock or hypoproteinemia. The fractionation of plasma has made available the albumins for use in shock and the specific globulins of value in measles, hemophilia, blood typing and blood clotting. The method has also succeeded in separating many of the smaller molecules which are not free in the blood stream but are in highly specific, more or less labile combination with the larger proteins. The fractionation process2 developed at Harvard Medical School yields all the components of human plasma in five major fractions. The physicochemical system on which the separation depends
FRACTIONATION OF BLOOD FOR THERAPEUTIC PURPOSES. JAMA. 1947;135(1):34–35. doi:10.1001/jama.1947.02890010036012
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