The kidneys, most marvelous anatomic structures in the body in Dock's1 opinion, work best while we sleep. Under such basal conditions their blood flow and work of excretion are maximal. When the body is violently active or under stress imposed by shock or hemorrhage, excretion and blood flow fall to extremely low levels.2 This paradoxical behavior was a remarkable discovery made by means of modern technics for measuring blood flow.
The extra oxygen consumed by the kidneys when the diet is changed from low protein to high protein is too small to be detected, and yet this change in diet leads to hypertrophy of the kidneys. In some types of renal injury the kidneys may be seriously jeopardized by a diet which supplies both urea and aromatic acids. The kidneys secrete aromatic acids five times as effectively as they filter off and concentrate urea.3 It may be
PECULIARITIES OF THE CIRCULATION IN THE KIDNEYS AND LIVER. JAMA. 1947;135(1):35–36. doi:10.1001/jama.1947.02890010037013
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