Hypervitaminosis A was first described in a case report by Josephs1 in 1944. Toomey and Morisette2 reported a similar case in 1947 and presented evidence that the symptom complex was the result of hypervitaminosis A and not hypervitaminosis D. Two additional cases were reported in 1948 by Rothman and Leon,3 who emphasized the roentgen observations. Since the patient of this report was examined by us, Dr. John Caffey reported 7 additional cases at the 1949 annual meeting of the American Pediatric Society.
SUMMARY OF PREVIOUS REPORTS
In previously reported cases the ages of the 4 patients were 3 years, 23 months, 14 months and 22 months. The parents in each case were extremely concerned about adequate vitamin administration, and in each instance there was a history of excessive dosage with vitamin concentrates. The predominant symptoms were anorexia, irritability, generalized pruritus and painful extremities, with a
WYATT TC, CARABELLO CA, FLETCHER ME. HYPERVITAMINOSIS AReport of a Case. JAMA. 1950;144(4):304–305. doi:10.1001/jama.1950.62920040002005a
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