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Article
August 21, 1954

ARTICULAR MANIFESTATIONS IN PULMONARY DISEASESAN ANALYSIS OF THEIR OCCURRENCE IN 1,024 CASES IN WHICH PULMONARY RESECTION WAS PERFORMED

JAMA. 1954;155(17):1459-1463. doi:10.1001/jama.1954.03690350001001
Abstract

Since the description by Hippocrates in the fifth century B. C. of clubbed fingers occurring in a patient with empyema, there has been recurrent interest in the articular manifestations of thoracic diseases. This interest has been intensified since a report by Craig1 in England in 1937 and Van Hazel2 in the United States in 1940 describing the joint changes occasionally seen in association with intrathoracic tumors. With the increasing incidence of bronchogenic carcinoma, other reports have appeared in the literature dealing with the articular manifestations as occasionally seen in conjunction with this lesion.

A discussion of this condition inevitably involves the term "hypertrophic pulmonary osteoarthropathy" and just how much this term should include. Although Marie's original definition employed the word "osteitis," which precludes simple clubbing that is a proliferative change of the soft tissues about the terminal phalanges, Locke3 stated, "Marie believes that the hippocratic fingers seen

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