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October 4, 1947


Author Affiliations


JAMA. 1947;135(5):306. doi:10.1001/jama.1947.02890050046018

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To the Editor:—  The recent current comment on Stability of Prothrombin in The Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts. In 1943 I reported in the American Journal of Physiology (140:212 [Nov.] 1943) my discovery that the delayed prothrombin time in stored plasma was due to the disappearance of a factor which was different from the prothrombin principle, which is reduced in "dicumarol" poisoning and which is adsorbable by aluminum trihydroxide, Al(OH)3. From these results I concluded that prothrombin was a complex and that one of the components was this labile factor whose activity was slowly diminished in stored plasma by oxidation. Recently Owren (Lancet1:446 [April 5] 1947) reported a case in which

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