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October 11, 1947

La digitale et les strophantines: Pharmacodynamie-thérapeutique

JAMA. 1947;135(6):395. doi:10.1001/jama.1947.02890060075035

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This monograph contains a review of the literature together with the author's own work in the field which dates back to the early nineteen hundreds. A consideration of the physiology of the autonomic nervous system in normal and pathologic states is followed by a discussion of the histology and the physiologic properties of the heart and blood vessels, and of their innervation. Then follows a comprehensive review of the literature dealing with the pharmacology of digitalis.

The author's concept regarding the mechanism of the action of digitalis and strophanthus preparations can be summed up as follows: The fact that digitalis drugs act in a manner similar to potassium and acetylcholine on certain properties of the heart and in a manner similar to calcium and epinephrine on others led him to the view that these drugs act to a large extent, but not exclusively, by cholinergic and adrenergic actions, the manner

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