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November 8, 1947


JAMA. 1947;135(10):644. doi:10.1001/jama.1947.02890100038008

In his introduction to a recent Conference on Nutrition in Relation to Cancer, Charles Glen King1 points out that definite gains have been made, although progress in the study of cancer may appear discouraging. Among 'these gains are stressed: 1. The establishment of the existence of a variety of definite, pure compounds that apparently initiate carcinogenesis and make it possible to project a research program on a molecular basis. Whether or not these compounds are similar to the common causative agents in human cancer is not known. 2. Several substances characteristic of natural diets can, under controlled conditions with animals, decide the issue of whether or not tumors will develop. Results with choline in the feeding of rats illustrate this strikingly. 3. Caloric intake, percentage and composition of ingested fat and certain members of the vitamin B complex, especially riboflavin and the more complex agents that can be transmitted

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