Intravenous clotting is an extremely undesirable complication because of its serious potentialities, which vary from sudden death to the development of persistent disabling sequelae. As we have previously emphasized, it is desirable to differentiate between two types of venous thrombosis, thrombophlebitis and phlebothrombosis. Thrombophlebitis, or phlegmasia alba dolens, usually causes severe symptoms which consist of fever, pain and swelling of the involved extremity. The clot in thrombophlebitis, which is secondary to inflammatory changes in the intima, is firmly attached to the vein wall and except in suppurative thrombophlebitis is not likely to become detached with the production of embolism. Because of this, fatalities are rare; but the persistence of disabling sequelae is the rule unless adequate therapy is instituted during the acute phase of the condition. On the other hand, in phlebothrombosis the intravenous clot is a coagulation thrombus resulting from two factors, of which one is predisposing and the
OCHSNER A, DeBAKEY ME, DeCAMP PT. VENOUS THROMBOSIS. JAMA. 1950;144(10):831–834. doi:10.1001/jama.1950.02920100019006
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