After a review of the literature, it would seem that the case reported herein is the first observation of Rh isoimmunization in a primipara, producing the severest form of congenital hemolytic disease, namely fetal hydrops, attributable to a previous intramuscular injection of Rho (D) blood in an Rh-negative woman. The mother as a child, fifteen years earlier, had been given an intramuscular injection of her father's blood, for successful prevention of measles following her exposure to the disease in a sibling.
That congenital hemolytic disease of the new born can occur in a small number of primigravid Rh-negative women as a result of previous transfusion of Rh-positive blood or previous abortion is now well recognized. Levine and Waller1 in 1946 reported observing 19 such instances in approximately 700 Rh-negative women. The 19 cases included 2 instances of fetal hydrops observed in 1944. Diamond2 and Tichenor3 have
SHARNOFF JG, JASPER JD. FETAL HYDROPS: Primipara Immunized by Previous Intramuscular Injection of Rho (D) Blood Report of a Case. JAMA. 1950;144(10):845–846. doi:10.1001/jama.1950.62920100011008a
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