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Article
October 30, 1954

EFFECT OF CIGARETTE SMOKE ON LUNG TUMORS OF LABORATORY ANIMALS

JAMA. 1954;156(9):909. doi:10.1001/jama.1954.02950090105020

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Abstract

To the Editor:—  I had the opportunity at the recent American Medical Association meeting in San Francisco to see the exhibit of Dr. Russell W. Weller of Philadelphia, and I would like to make a few comments. The title of his exhibit was "Lifetime Cigarette Smoke Exposure in a Colony of C-57 Black Mice."Four years ago, after finishing an experiment on cancer with A/Jax mice, I chose C-57 mice for my next study because these mice were known as "cancer-resistant." Forty experimental and 40 control mice were placed in my automatic smoking machine for intended exposure to the smoke for 14 months. The capacity of the smoking chamber of this machine is 2 cu. ft. (0.057 cu. m.); it smokes 12 cigarettes daily (one per hour) except Sundays. The smoke reaches the mice immediately and directly without loss of condensing tar. Fresh air circulates through the smoking chamber all

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