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December 6, 1947


JAMA. 1947;135(14):923-924. doi:10.1001/jama.1947.02890140043013

In 1937 Albright and his co-workers1 at the Massachusetts General Hospital described 5 cases characterized by bone lesions which have a tendency to be unilateral and which show osteitis fibrosa on histologic examination, brown nonelevated pigmented areas of the skin which tend to be on the same side as the bone lesions, and an endocrine dysfunction which in the female is associated with precocious puberty. The fact that the precosity did not occur in males suggested that this pathologic syndrome is due to a disturbance in the follicle stimulating hormone of the anterior pituitary. The bone lesions include multiple, circumscribed areas of what appears to be osteitis fibrosa with normal bone elsewhere. The term osteitis fibrosa disseminata was suggested to differentiate this entity from osteitis fibrosa generalisata of hyperparathyroidism and from osteitis fibrosa localisata (solitary bone cyst). The bone manifestations differ from hyperparathyroidism in that they are spotty rather

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