Despite the fact that many articles have appeared concerning the cause and elimination of pyrexial reactions after the administrations of solutions by vein, there still remains much lack of knowledge on the part of physicians and hospital personnel, so that these reactions still occur with a frequency inexcusable in the light of present day knowledge. Since most of the articles have appeared in technical or surgical journals they have escaped the eye of most of those responsible for the production of solutions and the care of tubing and needles, and therefore the application of the known successful methods of avoiding reactions has not become widespread. Commercial houses have, in general, attempted to correct the situation, but too often contact is made only with a purchasing agent who looks at the increased cost of material presented and refuses to buy it until forced to by the medical staff's complaints about reactions.
RADEMAKER L. REACTIONS TO INTRAVENOUS ADMINISTRATION OF SOLUTIONS. JAMA. 1947;135(17):1140–1141. doi:10.1001/jama.1947.02890170018005
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