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December 27, 1947


JAMA. 1947;135(17):1167. doi:10.1001/jama.1947.02890170045019

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To the Editor:—  Schistosome ova appearing in the excreta after a course of treatment are often attributed to reinfection rather than to an incomplete cure, though early Japanese investigators found it impossible to reinfect some animals in which the parasites had died out.On only one occasion have I had reason to believe that fresh infection has occurred with Schistosoma hematobium after a complete course of antimonium potassium tartrate has been administered, and it is possible that the natural death of schistosomes may produce the same immunity.This salt is sometimes supposed to be more toxic than its less stable sodium equivalent, but when it is dissolved in boiling water and passed through filter paper while still hot, the tendency of the patient to cough and vomit is avoided. An injection of 1 Gm. may well be regarded as the maximum.

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