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November 27, 1954


JAMA. 1954;156(13):1273. doi:10.1001/jama.1954.02950130055020

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To the Editor:—  Since Doan first called attention to the syndrome of hypersplenism, the existence of this entity has been confirmed by numerous observers. The beneficial effect of splenectomy in persons who have pancytopenia of this origin is further evidence supporting the concept of hypersplenism as a clinical entity. Surprisingly, up to now no note has been taken of the opposite clinical syndrome; in fact, the word hyposplenism does not appear in any of the standard medical dictionaries. Theoretically, persons with hyposplenism would be expected to show a high red blood cell count, high hemoglobin concentration, high leukocyte count, and high platelet count. Recently I had occasion to study a woman who had had a splenectomy performed two years previously and who showed all these findings and, in addition, had the very low sedimentation rate, by both Westergren and Wintrobe-Landsberg methods, of only 1 mm. per hour. But these are

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