Brilliant results obtained in the therapy of certain bacterial and spirochetal diseases by the use of chemical agents and antibiotics emphasize the absence of similar successes in the treatment of viral and rickettsial diseases. This difference between the response of bacterial and spirochetal diseases on the one hand and viral and rickettsial diseases on the other to chemotherapy is probably due to fundamental differences in the nature and metabolic activities of the two groups of disease-producing agents.
Although nothing similar to the therapeutic results obtained with bacterial and spirochetal diseases can be pointed to in the viral and rickettsial field, sufficient evidence has been obtained to warrant the hope that eventually chemotherapeutic agents and antibiotics will be found effective against maladies in the latter group. For instance, Meiklejohn and his associates1 and Wiseman and his associates2 have reported that penicillin and sulfadiazine have some therapeutic value when used
RIVERS TM. RECENT ADVANCES IN THE TREATMENT OF VIRAL AND RICKETTSIAL DISEASES. JAMA. 1948;136(5):291–292. doi:10.1001/jama.1948.02890220001001
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