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Article
January 31, 1948

RECENT ADVANCES IN THE TREATMENT OF CARDIOVASCULAR DISEASE

Author Affiliations

Rochester, Minn.

From the Division of Medicine, Mayo Clinic.

JAMA. 1948;136(5):299-304. doi:10.1001/jama.1948.02890220009003
Abstract

Advances in the treatment of heart disease rarely can be referred to any one year. Rather they represent increments of knowledge accumulated over many years. While the treatment of cardiovascular disease is ever progressing, the efficacy of certain advances has been sufficiently well established to warrant mention of them in this summary. In recent years an encouraging number of successful procedures in the treatment of heart disease have been devised which constitute real advances.

CONGESTIVE HEART FAILURE 

Digitalis.—  It is customary to standardize preparations of digitalis in terms of cat units, a unit being defined as the dose of the drug that is lethal for cats. It is unfortunate that glycosides of digitalis are tested for potency by intravenous administration whereas oral administration is more common when they are used clinically. Gold1 has shown that among preparations of digitalis there is a great variation in the degree of absorption.

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