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February 7, 1948

HUMAN BRUCELLOSIS: Its Specific Treatment with a Combination of Streptomycin and Sulfadiazine

Author Affiliations


From the Division of Internal Medicine, University of Minnesota Hospitals and Medical School, Minneapolis.; Dr. James Shaffer is Research Fellow in Chemotherapy under a grant from Commercial Solvents Corporation.

JAMA. 1948;136(6):382-387. doi:10.1001/jama.1948.02890230022005

Although brucellosis was one of the first infectious diseases for which Koch's postulates were established, specific therapy for this disease has remained in an unsatisfactory state. In 1936, Carpenter and Boak1 reviewed the therapeutic methods which had been used up to that time for human brucellosis and concluded that "a successful method for the treatment of brucellosis still awaits development." Fortunately, this timely survey of therapy by these authors appeared just before sulfanilamide was introduced for the treatment of bacterial infections. In the decade that has elapsed since sulfanilamide became available, other sulfonamide compounds and the antibiotics have appeared. This report embraces a series of experimental and clinical investigations on the specific therapy of brucellosis that have been carried out during the past ten years in the laboratories and clinics of the University of Minnesota Hospitals, and the results indicate that there is a more satisfactory approach to the