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February 14, 1948

The Influence of Positive Pressure Breathing on the Circulation in Man

JAMA. 1948;136(7):509. doi:10.1001/jama.1948.02890240075038

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This monograph reports a detailed investigation of three types of positive pressure breathing. The final recommendation "when positive pressure breathing is used for artificial respiration, the inspiratory period with high pressure should be short and the expiratory period should be long, with expiratory mean mask pressure as near atmospheric as possible" is supported by impressive observations of cardiac output and other hemodynamic variables. The monograph is recommended to all those who have occasion for positive pressure therapy, notably to anesthesiologists and those concerned with respirator design.

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