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January 15, 1955


JAMA. 1955;157(3):266. doi:10.1001/jama.1955.02950200064020

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To the Editor:—  I wish to call your attention to a letter by Dr. Gorelik in the Nov. 27, 1954, issue of The Journal, page 1274, in which he states that he has seen "several patients" who had a negative Master test and in whom acute coronary thrombosis developed a few hours later. Now, while an abnormal result in the double two-step test is not infrequently "false," especially under certain circumstances described by Master himself and others (for more details see my paper in New York J. Med.53:681 [March 15] 1953), the fact remains that the test under discussion is extremely valuable and reliable when its results is normal. As a matter of fact, I do not recall any other functional test with such a high degree of reliability when it is normal. Indeed, even such morphological tests as x-ray investigations and blood smears frequently yield falsely normal

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