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February 28, 1948

Hodgkin's Disease and Allied Disorders

JAMA. 1948;136(9):655. doi:10.1001/jama.1948.02890260063026

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Professors Jackson and Parker of Harvard are admirably qualified for this pathologic and clinical study of Hodgkin's disease and of related primary neoplasms of lymph nodes. This book represents the fruits of long study of a wealth of material, and its compilation obviously has been a labor of love.

The diagnosis of Hodgkin's disease must rest on a properly executed biopsy where the essential feature is the presence of Reed-Sternberg cells. The authors believe that Hodgkin's disease should be divided into three types, paragranuloma, granuloma and sarcoma, because the pathologic picture, clinical aspects and prognosis differ in each type; however, transition forms of these types occur. Paragranuloma is confined to lymph nodes and has a complete lack of invasiveness, but Hodgkin's granuloma, a more virulent disease, may involve and infiltrate any organ. The authors are of the opinion that the evidence bespeaks an infectious or inflammatory process for the first

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