One thousand and one tumors of the brain were verified in the neurosurgical service of the University and Graduate Hospitals of the University of Pennsylvania, between Jan. 1, 1936 and Jan. 1, 1947. Of these tumors, 101, or 10 per cent, were of pituitary origin, either intrasellar adenomas or extrasellar craniopharyngiomas. It is with the results of combined surgical and roentgen ray therapy of these lesions that this paper is concerned. Since intrasellar and extrasellar tumors differ somewhat in clinical manifestations and greatly in their response to either type of therapy, the two groups will be considered separately.
What benefit may be expected from the treatment of a pituitary tumor of either type? In none of the cases in this series in which a craniopharyngioma was verified were the glandular symptoms materially improved by any therapy—irradiation, endocrinologic or surgical. In 3 out of 4 cases in which diabetes insipidus was
GRANT FC. SURGICAL EXPERIENCE WITH TUMORS OF THE PITUITARY GLAND. JAMA. 1948;136(10):668–672. doi:10.1001/jama.1948.02890270010003
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