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January 22, 1955


JAMA. 1955;157(4):346. doi:10.1001/jama.1955.02950210042014

It has been estimated that about 200,000 Americans die each year from coronary occlusion with myocardial infarction and that more than 600,000 persons suffer attacks. In this connection, publication of the final report of the Committee on Anticoagulants of the American Heart Association1 is of considerable interest. This study of 1,031 patients, of whom about one-half received anticoagulants and the other half served as controls, provides an excellent example of a coordinated study conducted in 16 widely spread hospitals and involving the cooperation of about 100 investigators. The data were collected for more than two years and thereafter studied and evaluated for six years by a central laboratory team consisting of physicians, chemists, and statisticians.

In this series, the average age of the men was 57.9 years and of women 63.9 years. Angina was reported by 51% of the patients prior to the onset of myocardial infarction. Other evidence