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March 27, 1948

Antigonadotrophic Substances: Experimental and Clinical Studies on the Formation of Antigonadotrophic Substances Under Treatment with Gonadotrophic Hormones

JAMA. 1948;136(13):906. doi:10.1001/jama.1948.02890300056028

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This monograph contains an exhaustive review of the published reports on the existence, production and actions of antigonadotropic substances. The author has also included original data from his own investigations, derived both from laboratory and front clinical studies. Considerable attention is paid to immunologic relationships and the specificity of the various antihormones. The author appears to have demonstrated the production of antigonadotropins to heterologous gonadotropins but does not find evidence of their production following administration of homologous gonadotropins. He advances evidence that the gonadotropins are produced in the reticuloendothelial system and, like ordinary antibodies, are found in the globulin fraction of the serum. He also presents data tending to show that the biologically active part of the gonadotropin is a relatively simple chemical compound in combination with a protein component. The clinical studies are interesting because an explanation is offered for the difference in action of various gonadotropic substances in

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